Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss

RANKL is a cytokine produced as a membrane-bound and a secreted protein. Here, using mice lacking soluble RANKL, the authors show that the secreted protein is important for osteoclast function, but not for mammary gland and lymphocyte development.

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Bibliographic Details
Main Authors:	Jinhu Xiong, Keisha Cawley, Marilina Piemontese, Yuko Fujiwara, Haibo Zhao, Joseph J. Goellner, Charles A. O’Brien
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/f3fdb2bc80d5499aa847b891e2ea7b50
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spelling	oai:doaj.org-article:f3fdb2bc80d5499aa847b891e2ea7b502021-12-02T16:49:54ZSoluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss10.1038/s41467-018-05244-y2041-1723https://doaj.org/article/f3fdb2bc80d5499aa847b891e2ea7b502018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05244-yhttps://doaj.org/toc/2041-1723RANKL is a cytokine produced as a membrane-bound and a secreted protein. Here, using mice lacking soluble RANKL, the authors show that the secreted protein is important for osteoclast function, but not for mammary gland and lymphocyte development.Jinhu XiongKeisha CawleyMarilina PiemonteseYuko FujiwaraHaibo ZhaoJoseph J. GoellnerCharles A. O’BrienNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinhu Xiong Keisha Cawley Marilina Piemontese Yuko Fujiwara Haibo Zhao Joseph J. Goellner Charles A. O’Brien Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
description	RANKL is a cytokine produced as a membrane-bound and a secreted protein. Here, using mice lacking soluble RANKL, the authors show that the secreted protein is important for osteoclast function, but not for mammary gland and lymphocyte development.
format	article
author	Jinhu Xiong Keisha Cawley Marilina Piemontese Yuko Fujiwara Haibo Zhao Joseph J. Goellner Charles A. O’Brien
author_facet	Jinhu Xiong Keisha Cawley Marilina Piemontese Yuko Fujiwara Haibo Zhao Joseph J. Goellner Charles A. O’Brien
author_sort	Jinhu Xiong
title	Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
title_short	Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
title_full	Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
title_fullStr	Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
title_full_unstemmed	Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
title_sort	soluble rankl contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f3fdb2bc80d5499aa847b891e2ea7b50
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Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss

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