RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse

RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse

Abstract Protein kinases (PKs) are a class of druggable targets in Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (sleeping sickness), yet little is known about which PKs are essential for survival in mammals. A recent kinome-wide RNAi screen with 176 individual bloodstream...

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Bibliographic Details
Main Authors: Fernando Fernandez-Cortes, Tiago D. Serafim, Jonathan M. Wilkes, Nathaniel G. Jones, Ryan Ritchie, Richard McCulloch, Jeremy C. Mottram
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/f42ca3b4269e44a1a0bd4fab4c2527c1
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