Effects of Ruellia tuberosa L. Root Extract on the Pancreatics of Diabetic Rat

Diabetes mellitus type 1 (DMT1) is an insulin deficiency disorder caused by pancreatic damage characterized by chronic hyperglycemia. Animal modeling of DMT1 using inducting Multiple Low Dose Streptozotocin (MLD-STZ) elevat levels of free radicals and inflammation in pancreatic organs which then dam...

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Autores principales:	Muhammad Asadullah, Arie Srihardyastutie, Aulanni'am Aulanni'am
Formato:	article
Lenguaje:	EN
Publicado:	University of Brawijaya 2018
Materias:	ruellia tuberosa l malondialdehyde diabes mellitus flavonoids Chemistry QD1-999
Acceso en línea:	http://dx.doi.org/10.21776/ub.jpacr.2018.007.02.395 https://doaj.org/article/f45d888dd56c431dae04d3049d149c95
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spelling	oai:doaj.org-article:f45d888dd56c431dae04d3049d149c952021-12-02T13:34:13ZEffects of Ruellia tuberosa L. Root Extract on the Pancreatics of Diabetic Rathttp://dx.doi.org/10.21776/ub.jpacr.2018.007.02.3952302-46902302-4690https://doaj.org/article/f45d888dd56c431dae04d3049d149c952018-05-01T00:00:00Zhttps://jpacr.ub.ac.id/index.php/jpacr/article/view/395/pdfhttps://doaj.org/toc/2302-4690https://doaj.org/toc/2302-4690Diabetes mellitus type 1 (DMT1) is an insulin deficiency disorder caused by pancreatic damage characterized by chronic hyperglycemia. Animal modeling of DMT1 using inducting Multiple Low Dose Streptozotocin (MLD-STZ) elevat levels of free radicals and inflammation in pancreatic organs which then damage β cells. Ruellia tuberosa L. is a plant containing triterpenoids from the class of antioxidant and anti-inflammatory flavonoids. This study used three groups of rat: negative control group, positive control and 240 mg/kg bw therapy group. Study are based on changes MDA levels, blood glucose and histologic of pancreas. MDA level determining with TBA method, glucose levels using EasyTouch GCU and histopalogy of pancreas using Hematoxylin-Eosin staining. Statistical analysis of MDA and blood glucose (α = 0.05) showed significant decreases in MDA and blood glucose levels. Based on the results of histologic observations of pancreas descriptively showed a decreas in cell damage on Langerhans island. Thus, the provision of root extract of Ruellia tuberosa L. can inhibit the damage in rat DMT1 model so that it can be used as therapy of diabetes mellitus.Muhammad AsadullahArie SrihardyastutieAulanni'am Aulanni'amUniversity of Brawijayaarticleruellia tuberosa lmalondialdehydediabes mellitusflavonoidsChemistryQD1-999ENJournal of Pure and Applied Chemistry Research, Vol 7, Iss 2, Pp 116-121 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ruellia tuberosa l malondialdehyde diabes mellitus flavonoids Chemistry QD1-999
spellingShingle	ruellia tuberosa l malondialdehyde diabes mellitus flavonoids Chemistry QD1-999 Muhammad Asadullah Arie Srihardyastutie Aulanni'am Aulanni'am Effects of Ruellia tuberosa L. Root Extract on the Pancreatics of Diabetic Rat
description	Diabetes mellitus type 1 (DMT1) is an insulin deficiency disorder caused by pancreatic damage characterized by chronic hyperglycemia. Animal modeling of DMT1 using inducting Multiple Low Dose Streptozotocin (MLD-STZ) elevat levels of free radicals and inflammation in pancreatic organs which then damage β cells. Ruellia tuberosa L. is a plant containing triterpenoids from the class of antioxidant and anti-inflammatory flavonoids. This study used three groups of rat: negative control group, positive control and 240 mg/kg bw therapy group. Study are based on changes MDA levels, blood glucose and histologic of pancreas. MDA level determining with TBA method, glucose levels using EasyTouch GCU and histopalogy of pancreas using Hematoxylin-Eosin staining. Statistical analysis of MDA and blood glucose (α = 0.05) showed significant decreases in MDA and blood glucose levels. Based on the results of histologic observations of pancreas descriptively showed a decreas in cell damage on Langerhans island. Thus, the provision of root extract of Ruellia tuberosa L. can inhibit the damage in rat DMT1 model so that it can be used as therapy of diabetes mellitus.
format	article
author	Muhammad Asadullah Arie Srihardyastutie Aulanni'am Aulanni'am
author_facet	Muhammad Asadullah Arie Srihardyastutie Aulanni'am Aulanni'am
author_sort	Muhammad Asadullah
title	Effects of Ruellia tuberosa L. Root Extract on the Pancreatics of Diabetic Rat
title_short	Effects of Ruellia tuberosa L. Root Extract on the Pancreatics of Diabetic Rat
title_full	Effects of Ruellia tuberosa L. Root Extract on the Pancreatics of Diabetic Rat
title_fullStr	Effects of Ruellia tuberosa L. Root Extract on the Pancreatics of Diabetic Rat
title_full_unstemmed	Effects of Ruellia tuberosa L. Root Extract on the Pancreatics of Diabetic Rat
title_sort	effects of ruellia tuberosa l. root extract on the pancreatics of diabetic rat
publisher	University of Brawijaya
publishDate	2018
url	http://dx.doi.org/10.21776/ub.jpacr.2018.007.02.395 https://doaj.org/article/f45d888dd56c431dae04d3049d149c95
work_keys_str_mv	AT muhammadasadullah effectsofruelliatuberosalrootextractonthepancreaticsofdiabeticrat AT ariesrihardyastutie effectsofruelliatuberosalrootextractonthepancreaticsofdiabeticrat AT aulanniamaulanniam effectsofruelliatuberosalrootextractonthepancreaticsofdiabeticrat
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Effects of Ruellia tuberosa L. Root Extract on the Pancreatics of Diabetic Rat

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