Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models
Nagai et al. show that mice fed high-fat diet (HFD) accumulate oxidized low-density lipoprotein in macrophages through the renin–angiotensin system, which impairs visual function. They find that angiotensin II type 1 receptor (AT1R) improves the visual function of HFD mice, suggesting AT1R signaling...
Enregistré dans:
Auteurs principaux: | , , , , , , , , , , |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2020
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/f4787e8fdc4f4000a994a61c837651ea |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|