Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models

Nagai et al. show that mice fed high-fat diet (HFD) accumulate oxidized low-density lipoprotein in macrophages through the renin–angiotensin system, which impairs visual function. They find that angiotensin II type 1 receptor (AT1R) improves the visual function of HFD mice, suggesting AT1R signaling...

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Autores principales: Norihiro Nagai, Hirohiko Kawashima, Eriko Toda, Kohei Homma, Hideto Osada, Naymel A. Guzman, Shinsuke Shibata, Yasuo Uchiyama, Hideyuki Okano, Kazuo Tsubota, Yoko Ozawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/f4787e8fdc4f4000a994a61c837651ea
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