Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models

Nagai et al. show that mice fed high-fat diet (HFD) accumulate oxidized low-density lipoprotein in macrophages through the renin–angiotensin system, which impairs visual function. They find that angiotensin II type 1 receptor (AT1R) improves the visual function of HFD mice, suggesting AT1R signaling...

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Autores principales:	Norihiro Nagai, Hirohiko Kawashima, Eriko Toda, Kohei Homma, Hideto Osada, Naymel A. Guzman, Shinsuke Shibata, Yasuo Uchiyama, Hideyuki Okano, Kazuo Tsubota, Yoko Ozawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f4787e8fdc4f4000a994a61c837651ea
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spelling	oai:doaj.org-article:f4787e8fdc4f4000a994a61c837651ea2021-12-02T16:18:00ZRenin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models10.1038/s42003-020-01483-22399-3642https://doaj.org/article/f4787e8fdc4f4000a994a61c837651ea2020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01483-2https://doaj.org/toc/2399-3642Nagai et al. show that mice fed high-fat diet (HFD) accumulate oxidized low-density lipoprotein in macrophages through the renin–angiotensin system, which impairs visual function. They find that angiotensin II type 1 receptor (AT1R) improves the visual function of HFD mice, suggesting AT1R signaling as a potential therapeutic target for age-related macular degeneration.Norihiro NagaiHirohiko KawashimaEriko TodaKohei HommaHideto OsadaNaymel A. GuzmanShinsuke ShibataYasuo UchiyamaHideyuki OkanoKazuo TsubotaYoko OzawaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Norihiro Nagai Hirohiko Kawashima Eriko Toda Kohei Homma Hideto Osada Naymel A. Guzman Shinsuke Shibata Yasuo Uchiyama Hideyuki Okano Kazuo Tsubota Yoko Ozawa Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models
description	Nagai et al. show that mice fed high-fat diet (HFD) accumulate oxidized low-density lipoprotein in macrophages through the renin–angiotensin system, which impairs visual function. They find that angiotensin II type 1 receptor (AT1R) improves the visual function of HFD mice, suggesting AT1R signaling as a potential therapeutic target for age-related macular degeneration.
format	article
author	Norihiro Nagai Hirohiko Kawashima Eriko Toda Kohei Homma Hideto Osada Naymel A. Guzman Shinsuke Shibata Yasuo Uchiyama Hideyuki Okano Kazuo Tsubota Yoko Ozawa
author_facet	Norihiro Nagai Hirohiko Kawashima Eriko Toda Kohei Homma Hideto Osada Naymel A. Guzman Shinsuke Shibata Yasuo Uchiyama Hideyuki Okano Kazuo Tsubota Yoko Ozawa
author_sort	Norihiro Nagai
title	Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models
title_short	Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models
title_full	Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models
title_fullStr	Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models
title_full_unstemmed	Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models
title_sort	renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f4787e8fdc4f4000a994a61c837651ea
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Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models

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