Non-blocking modulation contributes to sodium channel inhibition by a covalently attached photoreactive riluzole analog

Abstract Sodium channel inhibitor drugs decrease pathological hyperactivity in various diseases including pain syndromes, myotonia, arrhythmias, nerve injuries and epilepsies. Inhibiting pathological but not physiological activity, however, is a major challenge in drug development. Sodium channel in...

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Autores principales: Peter Lukacs, Mátyás C. Földi, Luca Valánszki, Emilio Casanova, Beáta Biri-Kovács, László Nyitray, András Málnási-Csizmadia, Arpad Mike
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/f48d2435c9aa4403b15cfc5aca00707f
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