PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the mechanism of action.

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Autores principales:	Gabrielle J. Grundy, Luis M. Polo, Zhihong Zeng, Stuart L. Rulten, Nicolas C. Hoch, Pathompong Paomephan, Yingqi Xu, Steve M. Sweet, Alan W. Thorne, Antony W. Oliver, Steve J. Matthews, Laurence H. Pearl, Keith W. Caldecott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4adc148d44f418d9df058242e7f3bd6
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spelling	oai:doaj.org-article:f4adc148d44f418d9df058242e7f3bd62021-12-02T16:56:45ZPARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu210.1038/ncomms124042041-1723https://doaj.org/article/f4adc148d44f418d9df058242e7f3bd62016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12404https://doaj.org/toc/2041-1723Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the mechanism of action.Gabrielle J. GrundyLuis M. PoloZhihong ZengStuart L. RultenNicolas C. HochPathompong PaomephanYingqi XuSteve M. SweetAlan W. ThorneAntony W. OliverSteve J. MatthewsLaurence H. PearlKeith W. CaldecottNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabrielle J. Grundy Luis M. Polo Zhihong Zeng Stuart L. Rulten Nicolas C. Hoch Pathompong Paomephan Yingqi Xu Steve M. Sweet Alan W. Thorne Antony W. Oliver Steve J. Matthews Laurence H. Pearl Keith W. Caldecott PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2
description	Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the mechanism of action.
format	article
author	Gabrielle J. Grundy Luis M. Polo Zhihong Zeng Stuart L. Rulten Nicolas C. Hoch Pathompong Paomephan Yingqi Xu Steve M. Sweet Alan W. Thorne Antony W. Oliver Steve J. Matthews Laurence H. Pearl Keith W. Caldecott
author_facet	Gabrielle J. Grundy Luis M. Polo Zhihong Zeng Stuart L. Rulten Nicolas C. Hoch Pathompong Paomephan Yingqi Xu Steve M. Sweet Alan W. Thorne Antony W. Oliver Steve J. Matthews Laurence H. Pearl Keith W. Caldecott
author_sort	Gabrielle J. Grundy
title	PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2
title_short	PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2
title_full	PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2
title_fullStr	PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2
title_full_unstemmed	PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2
title_sort	parp3 is a sensor of nicked nucleosomes and monoribosylates histone h2bglu2
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f4adc148d44f418d9df058242e7f3bd6
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PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

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