Modified-release of encapsulated bioactive compounds from annatto seeds produced by optimized ionic gelation techniques

Abstract To compare the encapsulation of annatto extract by external gelation (EG) and internal gelation (IG) and to maximize process yield (% Y), two central composite designs were proposed. Calcium chloride (CaCl2) concentration (0.3–3.5%), alginate to gelling solution ratio (1:2–1:6); acetic acid...

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Autores principales:	Ana María Naranjo-Durán, Julián Quintero-Quiroz, John Rojas-Camargo, Gelmy Luz Ciro-Gómez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f4bfba46551f4651acb59ac514ac7009
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spelling	oai:doaj.org-article:f4bfba46551f4651acb59ac514ac70092021-12-02T14:01:20ZModified-release of encapsulated bioactive compounds from annatto seeds produced by optimized ionic gelation techniques10.1038/s41598-020-80119-12045-2322https://doaj.org/article/f4bfba46551f4651acb59ac514ac70092021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80119-1https://doaj.org/toc/2045-2322Abstract To compare the encapsulation of annatto extract by external gelation (EG) and internal gelation (IG) and to maximize process yield (% Y), two central composite designs were proposed. Calcium chloride (CaCl2) concentration (0.3–3.5%), alginate to gelling solution ratio (1:2–1:6); acetic acid (CH3COOH) concentration (0.2–5.0%) and alginate to gelling solution ratio (1:2–1:6) were taken as independent variables for EG and IG respectively. Release studies were conducted under different conditions; morphology, particle size, the encapsulation efficiency (EE), and release mechanism were evaluated under optimized conditions. The optimized EG conditions were 0.3% CaCl2 and 1:1.2 alginate to gelling solution ratio, whereas a 0.3% CH3COOH and 1:5 alginate to gelling solution ratio were optimized conditions for IG. When 20% extract was employed, the highest EE was achieved, and the largest release was obtained at a pH 6.5 buffer. The Peppas–Sahlin model presented the best fit to experimental data. Polyphenol release was driven by diffusion, whereas bixin showed anomalous release. These results are promising for application as modulated release agents in food matrices.Ana María Naranjo-DuránJulián Quintero-QuirozJohn Rojas-CamargoGelmy Luz Ciro-GómezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana María Naranjo-Durán Julián Quintero-Quiroz John Rojas-Camargo Gelmy Luz Ciro-Gómez Modified-release of encapsulated bioactive compounds from annatto seeds produced by optimized ionic gelation techniques
description	Abstract To compare the encapsulation of annatto extract by external gelation (EG) and internal gelation (IG) and to maximize process yield (% Y), two central composite designs were proposed. Calcium chloride (CaCl2) concentration (0.3–3.5%), alginate to gelling solution ratio (1:2–1:6); acetic acid (CH3COOH) concentration (0.2–5.0%) and alginate to gelling solution ratio (1:2–1:6) were taken as independent variables for EG and IG respectively. Release studies were conducted under different conditions; morphology, particle size, the encapsulation efficiency (EE), and release mechanism were evaluated under optimized conditions. The optimized EG conditions were 0.3% CaCl2 and 1:1.2 alginate to gelling solution ratio, whereas a 0.3% CH3COOH and 1:5 alginate to gelling solution ratio were optimized conditions for IG. When 20% extract was employed, the highest EE was achieved, and the largest release was obtained at a pH 6.5 buffer. The Peppas–Sahlin model presented the best fit to experimental data. Polyphenol release was driven by diffusion, whereas bixin showed anomalous release. These results are promising for application as modulated release agents in food matrices.
format	article
author	Ana María Naranjo-Durán Julián Quintero-Quiroz John Rojas-Camargo Gelmy Luz Ciro-Gómez
author_facet	Ana María Naranjo-Durán Julián Quintero-Quiroz John Rojas-Camargo Gelmy Luz Ciro-Gómez
author_sort	Ana María Naranjo-Durán
title	Modified-release of encapsulated bioactive compounds from annatto seeds produced by optimized ionic gelation techniques
title_short	Modified-release of encapsulated bioactive compounds from annatto seeds produced by optimized ionic gelation techniques
title_full	Modified-release of encapsulated bioactive compounds from annatto seeds produced by optimized ionic gelation techniques
title_fullStr	Modified-release of encapsulated bioactive compounds from annatto seeds produced by optimized ionic gelation techniques
title_full_unstemmed	Modified-release of encapsulated bioactive compounds from annatto seeds produced by optimized ionic gelation techniques
title_sort	modified-release of encapsulated bioactive compounds from annatto seeds produced by optimized ionic gelation techniques
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f4bfba46551f4651acb59ac514ac7009
work_keys_str_mv	AT anamarianaranjoduran modifiedreleaseofencapsulatedbioactivecompoundsfromannattoseedsproducedbyoptimizedionicgelationtechniques AT julianquinteroquiroz modifiedreleaseofencapsulatedbioactivecompoundsfromannattoseedsproducedbyoptimizedionicgelationtechniques AT johnrojascamargo modifiedreleaseofencapsulatedbioactivecompoundsfromannattoseedsproducedbyoptimizedionicgelationtechniques AT gelmyluzcirogomez modifiedreleaseofencapsulatedbioactivecompoundsfromannattoseedsproducedbyoptimizedionicgelationtechniques
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Modified-release of encapsulated bioactive compounds from annatto seeds produced by optimized ionic gelation techniques

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