GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

GABA transporters expressed in the striatum may affect behaviour. Here the authors investigate the contribution of GABA transporters on astrocytes to the regulation of dopamine release in the striatum, and show decreased expression of GAT-1 and GAT-3 in a mouse model of Parkinsonism.

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Autores principales:	Bradley M. Roberts, Natalie M. Doig, Katherine R. Brimblecombe, Emanuel F. Lopes, Ruth E. Siddorn, Sarah Threlfell, Natalie Connor-Robson, Nora Bengoa-Vergniory, Nicholas Pasternack, Richard Wade-Martins, Peter J. Magill, Stephanie J. Cragg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4c24c167c97494e92ebdf24a5229496
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spelling	oai:doaj.org-article:f4c24c167c97494e92ebdf24a52294962021-12-02T17:18:08ZGABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model10.1038/s41467-020-18247-52041-1723https://doaj.org/article/f4c24c167c97494e92ebdf24a52294962020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18247-5https://doaj.org/toc/2041-1723GABA transporters expressed in the striatum may affect behaviour. Here the authors investigate the contribution of GABA transporters on astrocytes to the regulation of dopamine release in the striatum, and show decreased expression of GAT-1 and GAT-3 in a mouse model of Parkinsonism.Bradley M. RobertsNatalie M. DoigKatherine R. BrimblecombeEmanuel F. LopesRuth E. SiddornSarah ThrelfellNatalie Connor-RobsonNora Bengoa-VergnioryNicholas PasternackRichard Wade-MartinsPeter J. MagillStephanie J. CraggNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bradley M. Roberts Natalie M. Doig Katherine R. Brimblecombe Emanuel F. Lopes Ruth E. Siddorn Sarah Threlfell Natalie Connor-Robson Nora Bengoa-Vergniory Nicholas Pasternack Richard Wade-Martins Peter J. Magill Stephanie J. Cragg GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
description	GABA transporters expressed in the striatum may affect behaviour. Here the authors investigate the contribution of GABA transporters on astrocytes to the regulation of dopamine release in the striatum, and show decreased expression of GAT-1 and GAT-3 in a mouse model of Parkinsonism.
format	article
author	Bradley M. Roberts Natalie M. Doig Katherine R. Brimblecombe Emanuel F. Lopes Ruth E. Siddorn Sarah Threlfell Natalie Connor-Robson Nora Bengoa-Vergniory Nicholas Pasternack Richard Wade-Martins Peter J. Magill Stephanie J. Cragg
author_facet	Bradley M. Roberts Natalie M. Doig Katherine R. Brimblecombe Emanuel F. Lopes Ruth E. Siddorn Sarah Threlfell Natalie Connor-Robson Nora Bengoa-Vergniory Nicholas Pasternack Richard Wade-Martins Peter J. Magill Stephanie J. Cragg
author_sort	Bradley M. Roberts
title	GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
title_short	GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
title_full	GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
title_fullStr	GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
title_full_unstemmed	GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
title_sort	gaba uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f4c24c167c97494e92ebdf24a5229496
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GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

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