AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates

The AID/APOBEC cytidine deaminase family are nucleic acid editors, important for antigen receptor expression and thought to have evolved along with vertebrate adaptive immunity. Here the authors show this family may have evolved prior to adaptive immunity as members with cytidine deaminase activity...

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Autores principales:	Mei-Chen Liu, Wen-Yun Liao, Katherine M. Buckley, Shu Yuan Yang, Jonathan P. Rast, Sebastian D. Fugmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4d7dc11f8f14ef7b2e471f8328fae2d
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spelling	oai:doaj.org-article:f4d7dc11f8f14ef7b2e471f8328fae2d2021-12-02T16:56:36ZAID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates10.1038/s41467-018-04273-x2041-1723https://doaj.org/article/f4d7dc11f8f14ef7b2e471f8328fae2d2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04273-xhttps://doaj.org/toc/2041-1723The AID/APOBEC cytidine deaminase family are nucleic acid editors, important for antigen receptor expression and thought to have evolved along with vertebrate adaptive immunity. Here the authors show this family may have evolved prior to adaptive immunity as members with cytidine deaminase activity are present and functional in invertebrate sea urchins and brachiopods.Mei-Chen LiuWen-Yun LiaoKatherine M. BuckleyShu Yuan YangJonathan P. RastSebastian D. FugmannNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mei-Chen Liu Wen-Yun Liao Katherine M. Buckley Shu Yuan Yang Jonathan P. Rast Sebastian D. Fugmann AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates
description	The AID/APOBEC cytidine deaminase family are nucleic acid editors, important for antigen receptor expression and thought to have evolved along with vertebrate adaptive immunity. Here the authors show this family may have evolved prior to adaptive immunity as members with cytidine deaminase activity are present and functional in invertebrate sea urchins and brachiopods.
format	article
author	Mei-Chen Liu Wen-Yun Liao Katherine M. Buckley Shu Yuan Yang Jonathan P. Rast Sebastian D. Fugmann
author_facet	Mei-Chen Liu Wen-Yun Liao Katherine M. Buckley Shu Yuan Yang Jonathan P. Rast Sebastian D. Fugmann
author_sort	Mei-Chen Liu
title	AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates
title_short	AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates
title_full	AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates
title_fullStr	AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates
title_full_unstemmed	AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates
title_sort	aid/apobec-like cytidine deaminases are ancient innate immune mediators in invertebrates
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f4d7dc11f8f14ef7b2e471f8328fae2d
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AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates

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