Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant

Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant

Manipulating DNA repair pathways can be used to improve the outcomes of CRISPR-based genome editing. Here the authors derive an enhanced RAD18 variant that suppresses 53BP1 recruitment to DNA double-strand breaks to enhance homology-mediated repair.

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Detalles Bibliográficos
Autores principales: Tarun S. Nambiar, Pierre Billon, Giacomo Diedenhofen, Samuel B. Hayward, Angelo Taglialatela, Kunheng Cai, Jen-Wei Huang, Giuseppe Leuzzi, Raquel Cuella-Martin, Andrew Palacios, Anuj Gupta, Dieter Egli, Alberto Ciccia
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/f4d885e322c6447198d8c7f4fa611f33
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