Fine mapping of the HLA locus in Parkinson’s disease in Europeans

Fine mapping of the HLA locus in Parkinson’s disease in Europeans

Abstract We fine mapped the leukocyte antigen (HLA) region in 13,770 Parkinson’s disease (PD) patients, 20,214 proxy-cases, and 490,861 controls of European origin. Four HLA types were associated with PD after correction for multiple comparisons, HLA-DQA1*03:01, HLA-DQB1*03:02, HLA-DRB1*04:01, and H...

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Autores principales: Eric Yu, Aditya Ambati, Maren Stolp Andersen, Lynne Krohn, Mehrdad A. Estiar, Prabhjyot Saini, Konstantin Senkevich, Yuri L. Sosero, Ashwin Ashok Kumar Sreelatha, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Mathias Toft, Marte K. Viken, Manu Sharma, Cornelis Blauwendraat, Lasse Pihlstrøm, Emmanuel Mignot, Ziv Gan-Or
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/f4f24fcd8c2b4d28bc704742820e3662
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https://doaj.org/article/f4f24fcd8c2b4d28bc704742820e3662

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