A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation

A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation

B-cell lymphoma/leukemia 11B (BCL11B) is a C2H2 zinc finger transcription factor that is critically important for regulating the development and function of a variety of systems including the central nervous system, the skin, and the immune system. Germline heterozygous variants are associated with...

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Autores principales: Henry Y. Lu, Robert Sertori, Alejandra V. Contreras, Mark Hamer, Melina Messing, Kate L. Del Bel, Elena Lopez-Rangel, Edmond S. Chan, Wingfield Rehmus, Joshua D. Milner, Kelly M. McNagny, Anna Lehman, David L. Wiest, Stuart E. Turvey
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
primary atopic disorders
inborn errors of immunity
primary immunodeficiencies
hyper IgE
BCL11B
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/f50e031de8ce43bcbc391ea6adbd0236
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https://doaj.org/article/f50e031de8ce43bcbc391ea6adbd0236

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