Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis

Grignard reagents have widespread utility in organic chemistry, but their preparation is limited by several drawbacks, such as the use of dry organic solvents and long reaction times. Here, the authors report a general mechanochemical synthesis of Grignard reagents in paste form in air, using a ball...

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Autores principales:	Rina Takahashi, Anqi Hu, Pan Gao, Yunpeng Gao, Yadong Pang, Tamae Seo, Julong Jiang, Satoshi Maeda, Hikaru Takaya, Koji Kubota, Hajime Ito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f50eccced71c431a8dfbdf97738db055
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spelling	oai:doaj.org-article:f50eccced71c431a8dfbdf97738db0552021-11-21T12:39:01ZMechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis10.1038/s41467-021-26962-w2041-1723https://doaj.org/article/f50eccced71c431a8dfbdf97738db0552021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26962-whttps://doaj.org/toc/2041-1723Grignard reagents have widespread utility in organic chemistry, but their preparation is limited by several drawbacks, such as the use of dry organic solvents and long reaction times. Here, the authors report a general mechanochemical synthesis of Grignard reagents in paste form in air, using a ball milling technique.Rina TakahashiAnqi HuPan GaoYunpeng GaoYadong PangTamae SeoJulong JiangSatoshi MaedaHikaru TakayaKoji KubotaHajime ItoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rina Takahashi Anqi Hu Pan Gao Yunpeng Gao Yadong Pang Tamae Seo Julong Jiang Satoshi Maeda Hikaru Takaya Koji Kubota Hajime Ito Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis
description	Grignard reagents have widespread utility in organic chemistry, but their preparation is limited by several drawbacks, such as the use of dry organic solvents and long reaction times. Here, the authors report a general mechanochemical synthesis of Grignard reagents in paste form in air, using a ball milling technique.
format	article
author	Rina Takahashi Anqi Hu Pan Gao Yunpeng Gao Yadong Pang Tamae Seo Julong Jiang Satoshi Maeda Hikaru Takaya Koji Kubota Hajime Ito
author_facet	Rina Takahashi Anqi Hu Pan Gao Yunpeng Gao Yadong Pang Tamae Seo Julong Jiang Satoshi Maeda Hikaru Takaya Koji Kubota Hajime Ito
author_sort	Rina Takahashi
title	Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis
title_short	Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis
title_full	Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis
title_fullStr	Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis
title_full_unstemmed	Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis
title_sort	mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f50eccced71c431a8dfbdf97738db055
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Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis

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