Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis

Kawakita et al use a murine sepsis model to show that N-glycan from pathogenic C. albicans ameliorates sepsis - and thus improves survival - through upregulation of the cytokine IL-10. This study demonstrates a potential strategy in which the immunosuppressive mechanism of one pathogen can be applie...

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Autores principales:	Masataka Kawakita, Taiki Oyama, Ikuma Shirai, Shuto Tanaka, Kotaro Akaki, Shinya Abe, Takuma Asahi, Guangwei Cui, Fumie Itoh, Masato Sasaki, Nobuyuki Shibata, Koichi Ikuta, Tomomitsu Hatakeyama, Kazuhiko Takahara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f517422173d447fa8da01bb742db42d0
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spelling	oai:doaj.org-article:f517422173d447fa8da01bb742db42d02021-12-02T17:05:09ZCell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis10.1038/s42003-021-01870-32399-3642https://doaj.org/article/f517422173d447fa8da01bb742db42d02021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01870-3https://doaj.org/toc/2399-3642Kawakita et al use a murine sepsis model to show that N-glycan from pathogenic C. albicans ameliorates sepsis - and thus improves survival - through upregulation of the cytokine IL-10. This study demonstrates a potential strategy in which the immunosuppressive mechanism of one pathogen can be applied to attenuate a severe inflammation caused by another pathogen.Masataka KawakitaTaiki OyamaIkuma ShiraiShuto TanakaKotaro AkakiShinya AbeTakuma AsahiGuangwei CuiFumie ItohMasato SasakiNobuyuki ShibataKoichi IkutaTomomitsu HatakeyamaKazuhiko TakaharaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Masataka Kawakita Taiki Oyama Ikuma Shirai Shuto Tanaka Kotaro Akaki Shinya Abe Takuma Asahi Guangwei Cui Fumie Itoh Masato Sasaki Nobuyuki Shibata Koichi Ikuta Tomomitsu Hatakeyama Kazuhiko Takahara Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis
description	Kawakita et al use a murine sepsis model to show that N-glycan from pathogenic C. albicans ameliorates sepsis - and thus improves survival - through upregulation of the cytokine IL-10. This study demonstrates a potential strategy in which the immunosuppressive mechanism of one pathogen can be applied to attenuate a severe inflammation caused by another pathogen.
format	article
author	Masataka Kawakita Taiki Oyama Ikuma Shirai Shuto Tanaka Kotaro Akaki Shinya Abe Takuma Asahi Guangwei Cui Fumie Itoh Masato Sasaki Nobuyuki Shibata Koichi Ikuta Tomomitsu Hatakeyama Kazuhiko Takahara
author_facet	Masataka Kawakita Taiki Oyama Ikuma Shirai Shuto Tanaka Kotaro Akaki Shinya Abe Takuma Asahi Guangwei Cui Fumie Itoh Masato Sasaki Nobuyuki Shibata Koichi Ikuta Tomomitsu Hatakeyama Kazuhiko Takahara
author_sort	Masataka Kawakita
title	Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis
title_short	Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis
title_full	Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis
title_fullStr	Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis
title_full_unstemmed	Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis
title_sort	cell wall n-glycan of candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f517422173d447fa8da01bb742db42d0
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Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis

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