Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response

Many RNA viruses that replicate in the cytoplasm express proteins that localize to nucleoli, but the nucleolar functions remain largely unknown. Here, the authors show that the Henipavirus matrix protein mimics an endogenous Treacle partner of the DNA-damage response, resulting in suppression of rRN...

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Autores principales:	Stephen M. Rawlinson, Tianyue Zhao, Ashley M. Rozario, Christina L. Rootes, Paul J. McMillan, Anthony W. Purcell, Amanda Woon, Glenn A. Marsh, Kim G. Lieu, Lin-Fa Wang, Hans J. Netter, Toby D. M. Bell, Cameron R. Stewart, Gregory W. Moseley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f56415c38df4400f9a9e20a5ceee7848
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spelling	oai:doaj.org-article:f56415c38df4400f9a9e20a5ceee78482021-12-02T15:34:49ZViral regulation of host cell biology by hijacking of the nucleolar DNA-damage response10.1038/s41467-018-05354-72041-1723https://doaj.org/article/f56415c38df4400f9a9e20a5ceee78482018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05354-7https://doaj.org/toc/2041-1723Many RNA viruses that replicate in the cytoplasm express proteins that localize to nucleoli, but the nucleolar functions remain largely unknown. Here, the authors show that the Henipavirus matrix protein mimics an endogenous Treacle partner of the DNA-damage response, resulting in suppression of rRNA biogenesis.Stephen M. RawlinsonTianyue ZhaoAshley M. RozarioChristina L. RootesPaul J. McMillanAnthony W. PurcellAmanda WoonGlenn A. MarshKim G. LieuLin-Fa WangHans J. NetterToby D. M. BellCameron R. StewartGregory W. MoseleyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen M. Rawlinson Tianyue Zhao Ashley M. Rozario Christina L. Rootes Paul J. McMillan Anthony W. Purcell Amanda Woon Glenn A. Marsh Kim G. Lieu Lin-Fa Wang Hans J. Netter Toby D. M. Bell Cameron R. Stewart Gregory W. Moseley Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response
description	Many RNA viruses that replicate in the cytoplasm express proteins that localize to nucleoli, but the nucleolar functions remain largely unknown. Here, the authors show that the Henipavirus matrix protein mimics an endogenous Treacle partner of the DNA-damage response, resulting in suppression of rRNA biogenesis.
format	article
author	Stephen M. Rawlinson Tianyue Zhao Ashley M. Rozario Christina L. Rootes Paul J. McMillan Anthony W. Purcell Amanda Woon Glenn A. Marsh Kim G. Lieu Lin-Fa Wang Hans J. Netter Toby D. M. Bell Cameron R. Stewart Gregory W. Moseley
author_facet	Stephen M. Rawlinson Tianyue Zhao Ashley M. Rozario Christina L. Rootes Paul J. McMillan Anthony W. Purcell Amanda Woon Glenn A. Marsh Kim G. Lieu Lin-Fa Wang Hans J. Netter Toby D. M. Bell Cameron R. Stewart Gregory W. Moseley
author_sort	Stephen M. Rawlinson
title	Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response
title_short	Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response
title_full	Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response
title_fullStr	Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response
title_full_unstemmed	Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response
title_sort	viral regulation of host cell biology by hijacking of the nucleolar dna-damage response
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f56415c38df4400f9a9e20a5ceee7848
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Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response

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