Maternal vaccination and protective immunity against Zika virus vertical transmission

A Zika virus vaccine should protect the fetus during pregnancy. Here, using a live-attenuated Zika vaccine, the authors show that a higher neutralizing antibody titer is required to protect from in utero transmission than to protect non-pregnant mice and that a single maternal immunization protects...

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Autores principales:	Chao Shan, Xuping Xie, Huanle Luo, Antonio E. Muruato, Yang Liu, Maki Wakamiya, Jun-Ho La, Jin Mo Chung, Scott C. Weaver, Tian Wang, Pei-Yong Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5695ee8d606486d80040a70ba0f34f0
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spelling	oai:doaj.org-article:f5695ee8d606486d80040a70ba0f34f02021-12-02T14:39:41ZMaternal vaccination and protective immunity against Zika virus vertical transmission10.1038/s41467-019-13589-12041-1723https://doaj.org/article/f5695ee8d606486d80040a70ba0f34f02019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13589-1https://doaj.org/toc/2041-1723A Zika virus vaccine should protect the fetus during pregnancy. Here, using a live-attenuated Zika vaccine, the authors show that a higher neutralizing antibody titer is required to protect from in utero transmission than to protect non-pregnant mice and that a single maternal immunization protects the fetus from infection and disease.Chao ShanXuping XieHuanle LuoAntonio E. MuruatoYang LiuMaki WakamiyaJun-Ho LaJin Mo ChungScott C. WeaverTian WangPei-Yong ShiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chao Shan Xuping Xie Huanle Luo Antonio E. Muruato Yang Liu Maki Wakamiya Jun-Ho La Jin Mo Chung Scott C. Weaver Tian Wang Pei-Yong Shi Maternal vaccination and protective immunity against Zika virus vertical transmission
description	A Zika virus vaccine should protect the fetus during pregnancy. Here, using a live-attenuated Zika vaccine, the authors show that a higher neutralizing antibody titer is required to protect from in utero transmission than to protect non-pregnant mice and that a single maternal immunization protects the fetus from infection and disease.
format	article
author	Chao Shan Xuping Xie Huanle Luo Antonio E. Muruato Yang Liu Maki Wakamiya Jun-Ho La Jin Mo Chung Scott C. Weaver Tian Wang Pei-Yong Shi
author_facet	Chao Shan Xuping Xie Huanle Luo Antonio E. Muruato Yang Liu Maki Wakamiya Jun-Ho La Jin Mo Chung Scott C. Weaver Tian Wang Pei-Yong Shi
author_sort	Chao Shan
title	Maternal vaccination and protective immunity against Zika virus vertical transmission
title_short	Maternal vaccination and protective immunity against Zika virus vertical transmission
title_full	Maternal vaccination and protective immunity against Zika virus vertical transmission
title_fullStr	Maternal vaccination and protective immunity against Zika virus vertical transmission
title_full_unstemmed	Maternal vaccination and protective immunity against Zika virus vertical transmission
title_sort	maternal vaccination and protective immunity against zika virus vertical transmission
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f5695ee8d606486d80040a70ba0f34f0
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Maternal vaccination and protective immunity against Zika virus vertical transmission

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