High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma.

High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma.

Classical tumor suppressor genes block neoplasia by regulating cell growth and death. A remarkable puzzle is therefore presented by familial paraganglioma (PGL), a neuroendocrine cancer where the tumor suppressor genes encode subunits of succinate dehydrogenase (SDH), an enzyme of the tricarboxylic...

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Autores principales: Irina Bancos, John Paul Bida, Defeng Tian, Mary Bundrick, Kristen John, Molly Nelson Holte, Yeng F Her, Debra Evans, Dyana T Saenz, Eric M Poeschla, Derek Hook, Gunda Georg, L James Maher
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/f59d566d9d2d4a60a0109f1d98d39a5c
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