Genomic footprints of activated telomere maintenance mechanisms in cancer

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with di...

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Autores principales:	Lina Sieverling, Chen Hong, Sandra D. Koser, Philip Ginsbach, Kortine Kleinheinz, Barbara Hutter, Delia M. Braun, Isidro Cortés-Ciriano, Ruibin Xi, Rolf Kabbe, Peter J. Park, Roland Eils, Matthias Schlesner, PCAWG-Structural Variation Working Group, Benedikt Brors, Karsten Rippe, David T. W. Jones, Lars Feuerbach, PCAWG Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5ba2ff084914f529104ae4627a4c3f7
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spelling	oai:doaj.org-article:f5ba2ff084914f529104ae4627a4c3f72021-12-02T17:32:28ZGenomic footprints of activated telomere maintenance mechanisms in cancer10.1038/s41467-019-13824-92041-1723https://doaj.org/article/f5ba2ff084914f529104ae4627a4c3f72020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13824-9https://doaj.org/toc/2041-1723In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.Lina SieverlingChen HongSandra D. KoserPhilip GinsbachKortine KleinheinzBarbara HutterDelia M. BraunIsidro Cortés-CirianoRuibin XiRolf KabbePeter J. ParkRoland EilsMatthias SchlesnerPCAWG-Structural Variation Working GroupBenedikt BrorsKarsten RippeDavid T. W. JonesLars FeuerbachPCAWG ConsortiumNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lina Sieverling Chen Hong Sandra D. Koser Philip Ginsbach Kortine Kleinheinz Barbara Hutter Delia M. Braun Isidro Cortés-Ciriano Ruibin Xi Rolf Kabbe Peter J. Park Roland Eils Matthias Schlesner PCAWG-Structural Variation Working Group Benedikt Brors Karsten Rippe David T. W. Jones Lars Feuerbach PCAWG Consortium Genomic footprints of activated telomere maintenance mechanisms in cancer
description	In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.
format	article
author	Lina Sieverling Chen Hong Sandra D. Koser Philip Ginsbach Kortine Kleinheinz Barbara Hutter Delia M. Braun Isidro Cortés-Ciriano Ruibin Xi Rolf Kabbe Peter J. Park Roland Eils Matthias Schlesner PCAWG-Structural Variation Working Group Benedikt Brors Karsten Rippe David T. W. Jones Lars Feuerbach PCAWG Consortium
author_facet	Lina Sieverling Chen Hong Sandra D. Koser Philip Ginsbach Kortine Kleinheinz Barbara Hutter Delia M. Braun Isidro Cortés-Ciriano Ruibin Xi Rolf Kabbe Peter J. Park Roland Eils Matthias Schlesner PCAWG-Structural Variation Working Group Benedikt Brors Karsten Rippe David T. W. Jones Lars Feuerbach PCAWG Consortium
author_sort	Lina Sieverling
title	Genomic footprints of activated telomere maintenance mechanisms in cancer
title_short	Genomic footprints of activated telomere maintenance mechanisms in cancer
title_full	Genomic footprints of activated telomere maintenance mechanisms in cancer
title_fullStr	Genomic footprints of activated telomere maintenance mechanisms in cancer
title_full_unstemmed	Genomic footprints of activated telomere maintenance mechanisms in cancer
title_sort	genomic footprints of activated telomere maintenance mechanisms in cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f5ba2ff084914f529104ae4627a4c3f7
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Genomic footprints of activated telomere maintenance mechanisms in cancer

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