High-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domain.

Monoclonal and recombinant antibodies are ubiquitous tools in diagnostics, therapeutics, and biotechnology. However, their biochemical properties lack optimal robustness, their bacterial production is not easy, and possibilities to create multifunctional fusion proteins based on them are limited. Mo...

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Autores principales: Annika Järviluoma, Tomas Strandin, Sebastian Lülf, Jérôme Bouchet, Anna R Mäkelä, Matthias Geyer, Serge Benichou, Kalle Saksela
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/f5d5bb140c814e85a52a5463f9b77ddf
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