Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis

Kitazawa et al. show that chondroitin 6-sulfate represses keratinocyte proliferation in skin. They find that mice deficient in chondroitin-6-O-sulfotransferase-1 (C6st-1), which synthesizes chondroitin 6-sulfate, exhibit keratinocyte hyperproliferation and impaired skin permeability barrier. This st...

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Autores principales:	Kazuyuki Kitazawa, Satomi Nadanaka, Kenji Kadomatsu, Hiroshi Kitagawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f5ee692e9c0645bdbe1c36a9b082fc46
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spelling	oai:doaj.org-article:f5ee692e9c0645bdbe1c36a9b082fc462021-12-02T10:47:53ZChondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis10.1038/s42003-020-01618-52399-3642https://doaj.org/article/f5ee692e9c0645bdbe1c36a9b082fc462021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01618-5https://doaj.org/toc/2399-3642Kitazawa et al. show that chondroitin 6-sulfate represses keratinocyte proliferation in skin. They find that mice deficient in chondroitin-6-O-sulfotransferase-1 (C6st-1), which synthesizes chondroitin 6-sulfate, exhibit keratinocyte hyperproliferation and impaired skin permeability barrier. This study suggests that the expression level of C6st-1 may serve as a biomarker for the susceptibility to psoriasis.Kazuyuki KitazawaSatomi NadanakaKenji KadomatsuHiroshi KitagawaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Kazuyuki Kitazawa Satomi Nadanaka Kenji Kadomatsu Hiroshi Kitagawa Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis
description	Kitazawa et al. show that chondroitin 6-sulfate represses keratinocyte proliferation in skin. They find that mice deficient in chondroitin-6-O-sulfotransferase-1 (C6st-1), which synthesizes chondroitin 6-sulfate, exhibit keratinocyte hyperproliferation and impaired skin permeability barrier. This study suggests that the expression level of C6st-1 may serve as a biomarker for the susceptibility to psoriasis.
format	article
author	Kazuyuki Kitazawa Satomi Nadanaka Kenji Kadomatsu Hiroshi Kitagawa
author_facet	Kazuyuki Kitazawa Satomi Nadanaka Kenji Kadomatsu Hiroshi Kitagawa
author_sort	Kazuyuki Kitazawa
title	Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis
title_short	Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis
title_full	Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis
title_fullStr	Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis
title_full_unstemmed	Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis
title_sort	chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f5ee692e9c0645bdbe1c36a9b082fc46
work_keys_str_mv	AT kazuyukikitazawa chondroitin6sulfaterepresseskeratinocyteproliferationinmouseskinwhichisassociatedwithpsoriasis AT satominadanaka chondroitin6sulfaterepresseskeratinocyteproliferationinmouseskinwhichisassociatedwithpsoriasis AT kenjikadomatsu chondroitin6sulfaterepresseskeratinocyteproliferationinmouseskinwhichisassociatedwithpsoriasis AT hiroshikitagawa chondroitin6sulfaterepresseskeratinocyteproliferationinmouseskinwhichisassociatedwithpsoriasis
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Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis

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