Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis

Kitazawa et al. show that chondroitin 6-sulfate represses keratinocyte proliferation in skin. They find that mice deficient in chondroitin-6-O-sulfotransferase-1 (C6st-1), which synthesizes chondroitin 6-sulfate, exhibit keratinocyte hyperproliferation and impaired skin permeability barrier. This st...

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Autores principales: Kazuyuki Kitazawa, Satomi Nadanaka, Kenji Kadomatsu, Hiroshi Kitagawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f5ee692e9c0645bdbe1c36a9b082fc46
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