The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis.

Motile cells are capable of sensing the stiffness of the surrounding extracellular matrix through integrin-mediated focal adhesions and migrate towards regions of higher rigidity in a process known as durotaxis. Durotaxis plays an important role in normal development and disease progression, includi...

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Autores principales: Duncan B Wormer, Kevin A Davis, James H Henderson, Christopher E Turner
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/f62dc6c97b60473e96a1d0496e88fca0
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