The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis.
Motile cells are capable of sensing the stiffness of the surrounding extracellular matrix through integrin-mediated focal adhesions and migrate towards regions of higher rigidity in a process known as durotaxis. Durotaxis plays an important role in normal development and disease progression, includi...
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Autores principales: | Duncan B Wormer, Kevin A Davis, James H Henderson, Christopher E Turner |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2014
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Materias: | |
Acceso en línea: | https://doaj.org/article/f62dc6c97b60473e96a1d0496e88fca0 |
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