PIAS1 alleviates diabetic peripheral neuropathy through SUMOlation of PPAR-γ and miR-124-induced downregulation of EZH2/STAT3

Abstract Diabetic peripheral neuropathy (DPN) is a frequently occurring chronic complication of diabetes. In this study, we aim to explore the regulatory mechanism of protein inhibitor of activated STAT1 (PIAS1) in DPN in terms of autophagy and apoptosis of Schwann cells. The SUMOlation of PPAR-γ by...

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Bibliographic Details
Main Authors: Zixin Hou, Ji Chen, Huan Yang, Xiaoling Hu, Fengrui Yang
Format: article
Language:EN
Published: Nature Publishing Group 2021
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Online Access:https://doaj.org/article/f64abc113d014cc5bcda7aa273c9bb50
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