Involvement of classic and alternative non-homologous end joining pathways in hematologic malignancies: targeting strategies for treatment

Involvement of classic and alternative non-homologous end joining pathways in hematologic malignancies: targeting strategies for treatment

Abstract Chromosomal translocations are the main etiological factor of hematologic malignancies. These translocations are generally the consequence of aberrant DNA double-strand break (DSB) repair. DSBs arise either exogenously or endogenously in cells and are repaired by major pathways, including n...

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Autores principales: Mohsen Valikhani, Elahe Rahimian, Seyed Esmaeil Ahmadi, Rouzbeh Chegeni, Majid Safa
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Double-strand break
Double-strand break repair
Non-homologous end-joining
Alternative end-joining pathways
Hematologic malignancies
Targeted therapy
Diseases of the blood and blood-forming organs
RC633-647.5
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/f65821dddac94eee87c69283e2a72504
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https://doaj.org/article/f65821dddac94eee87c69283e2a72504

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