ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation

ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation

Abstract Mutations in Fused in Sarcoma/Translocated in Liposarcoma (FUS) cause familial forms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by progressive axonal degeneration mainly affecting motor neurons. Evidence from transgenic mouse models suggests mutant for...

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Autores principales: Reddy Ranjith K. Sama, Claudia Fallini, Rodolfo Gatto, Jeanne E. McKeon, Yuyu Song, Melissa S. Rotunno, Saul Penaranda, Izrail Abdurakhmanov, John E. Landers, Gerardo Morfini, Scott T. Brady, Daryl A. Bosco
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/f67025a8d9b84438822ee997bac6b02a
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https://doaj.org/article/f67025a8d9b84438822ee997bac6b02a

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