Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB

Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB

AcrB is a prototypical resistance–nodulation–division (RND) bacterial transporter, conferring resistance to a variety of antibiotics. HDX-MS and other, complementary approaches offer insight into AcrB structural dynamics and suggest the molecular mechanisms underlying drug export and inhibition of t...

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Autores principales: Eamonn Reading, Zainab Ahdash, Chiara Fais, Vito Ricci, Xuan Wang-Kan, Elizabeth Grimsey, Jack Stone, Giuliano Malloci, Andy M. Lau, Heather Findlay, Albert Konijnenberg, Paula J. Booth, Paolo Ruggerone, Attilio V. Vargiu, Laura J. V. Piddock, Argyris Politis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/f67d2dabeba6419d899fd8c49aa914be
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Sumario:AcrB is a prototypical resistance–nodulation–division (RND) bacterial transporter, conferring resistance to a variety of antibiotics. HDX-MS and other, complementary approaches offer insight into AcrB structural dynamics and suggest the molecular mechanisms underlying drug export and inhibition of this multidrug-resistance conferring pump.

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