Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB

AcrB is a prototypical resistance–nodulation–division (RND) bacterial transporter, conferring resistance to a variety of antibiotics. HDX-MS and other, complementary approaches offer insight into AcrB structural dynamics and suggest the molecular mechanisms underlying drug export and inhibition of t...

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Autores principales:	Eamonn Reading, Zainab Ahdash, Chiara Fais, Vito Ricci, Xuan Wang-Kan, Elizabeth Grimsey, Jack Stone, Giuliano Malloci, Andy M. Lau, Heather Findlay, Albert Konijnenberg, Paula J. Booth, Paolo Ruggerone, Attilio V. Vargiu, Laura J. V. Piddock, Argyris Politis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f67d2dabeba6419d899fd8c49aa914be
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spelling	oai:doaj.org-article:f67d2dabeba6419d899fd8c49aa914be2021-12-02T16:49:47ZPerturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB10.1038/s41467-020-19397-22041-1723https://doaj.org/article/f67d2dabeba6419d899fd8c49aa914be2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19397-2https://doaj.org/toc/2041-1723AcrB is a prototypical resistance–nodulation–division (RND) bacterial transporter, conferring resistance to a variety of antibiotics. HDX-MS and other, complementary approaches offer insight into AcrB structural dynamics and suggest the molecular mechanisms underlying drug export and inhibition of this multidrug-resistance conferring pump.Eamonn ReadingZainab AhdashChiara FaisVito RicciXuan Wang-KanElizabeth GrimseyJack StoneGiuliano MallociAndy M. LauHeather FindlayAlbert KonijnenbergPaula J. BoothPaolo RuggeroneAttilio V. VargiuLaura J. V. PiddockArgyris PolitisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eamonn Reading Zainab Ahdash Chiara Fais Vito Ricci Xuan Wang-Kan Elizabeth Grimsey Jack Stone Giuliano Malloci Andy M. Lau Heather Findlay Albert Konijnenberg Paula J. Booth Paolo Ruggerone Attilio V. Vargiu Laura J. V. Piddock Argyris Politis Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB
description	AcrB is a prototypical resistance–nodulation–division (RND) bacterial transporter, conferring resistance to a variety of antibiotics. HDX-MS and other, complementary approaches offer insight into AcrB structural dynamics and suggest the molecular mechanisms underlying drug export and inhibition of this multidrug-resistance conferring pump.
format	article
author	Eamonn Reading Zainab Ahdash Chiara Fais Vito Ricci Xuan Wang-Kan Elizabeth Grimsey Jack Stone Giuliano Malloci Andy M. Lau Heather Findlay Albert Konijnenberg Paula J. Booth Paolo Ruggerone Attilio V. Vargiu Laura J. V. Piddock Argyris Politis
author_facet	Eamonn Reading Zainab Ahdash Chiara Fais Vito Ricci Xuan Wang-Kan Elizabeth Grimsey Jack Stone Giuliano Malloci Andy M. Lau Heather Findlay Albert Konijnenberg Paula J. Booth Paolo Ruggerone Attilio V. Vargiu Laura J. V. Piddock Argyris Politis
author_sort	Eamonn Reading
title	Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB
title_short	Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB
title_full	Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB
title_fullStr	Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB
title_full_unstemmed	Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB
title_sort	perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump acrb
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f67d2dabeba6419d899fd8c49aa914be
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Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB

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