Knockdown of SENP1 inhibits HIF-1α SUMOylation and suppresses oncogenic CCNE1 in Wilms tumor

Knockdown of SENP1 inhibits HIF-1α SUMOylation and suppresses oncogenic CCNE1 in Wilms tumor

Based on our initial bioinformatics finding of the upregulated expression of sentrin-specific protease 1 (SENP1) and cyclin E1 (CCNE1) in Wilms tumor, this study aimed to illustrate the molecular mechanism of SENP1 in Wilms tumor, which involved the hypoxia-inducible factor 1α (HIF-1α)/stanniocalcin...

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Detalles Bibliográficos
Autores principales: Shibo Zhu, Jinhua Hu, Yanhong Cui, Shen Liang, Xiaofeng Gao, Jin Zhang, Wei Jia
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
Wilms tumor
SENP1
HIF-1α
SUMOylation
STC1
CCNE1
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/f67ea92b186f4418bb3411eb1cdb3116
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https://doaj.org/article/f67ea92b186f4418bb3411eb1cdb3116

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