The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability

The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability

Histone methylation regulates gene expression. Here, Salifou et al.show that KDM4A, a histone lysine demethylase, regulates RNA polymerase I-driven transcription in a PI3K dependent manner, therefore linking nutrients and growth factors availability to ribosomal RNA transcription.

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Autores principales: Kader Salifou, Swagat Ray, Laure Verrier, Marion Aguirrebengoa, Didier Trouche, Konstantin I. Panov, Marie Vandromme
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/f68c012eaa2d4999844a9ef3bbf50a85
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spelling oai:doaj.org-article:f68c012eaa2d4999844a9ef3bbf50a852021-12-02T16:56:48ZThe histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability10.1038/ncomms101742041-1723https://doaj.org/article/f68c012eaa2d4999844a9ef3bbf50a852016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10174https://doaj.org/toc/2041-1723Histone methylation regulates gene expression. Here, Salifou et al.show that KDM4A, a histone lysine demethylase, regulates RNA polymerase I-driven transcription in a PI3K dependent manner, therefore linking nutrients and growth factors availability to ribosomal RNA transcription.Kader SalifouSwagat RayLaure VerrierMarion AguirrebengoaDidier TroucheKonstantin I. PanovMarie VandrommeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kader Salifou
Swagat Ray
Laure Verrier
Marion Aguirrebengoa
Didier Trouche
Konstantin I. Panov
Marie Vandromme
The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
description Histone methylation regulates gene expression. Here, Salifou et al.show that KDM4A, a histone lysine demethylase, regulates RNA polymerase I-driven transcription in a PI3K dependent manner, therefore linking nutrients and growth factors availability to ribosomal RNA transcription.
format article
author Kader Salifou
Swagat Ray
Laure Verrier
Marion Aguirrebengoa
Didier Trouche
Konstantin I. Panov
Marie Vandromme
author_facet Kader Salifou
Swagat Ray
Laure Verrier
Marion Aguirrebengoa
Didier Trouche
Konstantin I. Panov
Marie Vandromme
author_sort Kader Salifou
title The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
title_short The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
title_full The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
title_fullStr The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
title_full_unstemmed The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
title_sort histone demethylase jmjd2a/kdm4a links ribosomal rna transcription to nutrients and growth factors availability
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/f68c012eaa2d4999844a9ef3bbf50a85
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