Large-scale network analysis reveals the sequence space architecture of antibody repertoires

Analysis of large-scale immune repertoire architecture remains a challenge. Here, the authors introduce an approach to construct similarity networks from high-throughput antibody repertoire sequencing data, and show that the networks are redundant, robust and reproducible across individuals.

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Autores principales:	Enkelejda Miho, Rok Roškar, Victor Greiff, Sai T. Reddy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6972148747046a6ac850662095375ec
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spelling	oai:doaj.org-article:f6972148747046a6ac850662095375ec2021-12-02T17:32:40ZLarge-scale network analysis reveals the sequence space architecture of antibody repertoires10.1038/s41467-019-09278-82041-1723https://doaj.org/article/f6972148747046a6ac850662095375ec2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09278-8https://doaj.org/toc/2041-1723Analysis of large-scale immune repertoire architecture remains a challenge. Here, the authors introduce an approach to construct similarity networks from high-throughput antibody repertoire sequencing data, and show that the networks are redundant, robust and reproducible across individuals.Enkelejda MihoRok RoškarVictor GreiffSai T. ReddyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Enkelejda Miho Rok Roškar Victor Greiff Sai T. Reddy Large-scale network analysis reveals the sequence space architecture of antibody repertoires
description	Analysis of large-scale immune repertoire architecture remains a challenge. Here, the authors introduce an approach to construct similarity networks from high-throughput antibody repertoire sequencing data, and show that the networks are redundant, robust and reproducible across individuals.
format	article
author	Enkelejda Miho Rok Roškar Victor Greiff Sai T. Reddy
author_facet	Enkelejda Miho Rok Roškar Victor Greiff Sai T. Reddy
author_sort	Enkelejda Miho
title	Large-scale network analysis reveals the sequence space architecture of antibody repertoires
title_short	Large-scale network analysis reveals the sequence space architecture of antibody repertoires
title_full	Large-scale network analysis reveals the sequence space architecture of antibody repertoires
title_fullStr	Large-scale network analysis reveals the sequence space architecture of antibody repertoires
title_full_unstemmed	Large-scale network analysis reveals the sequence space architecture of antibody repertoires
title_sort	large-scale network analysis reveals the sequence space architecture of antibody repertoires
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f6972148747046a6ac850662095375ec
work_keys_str_mv	AT enkelejdamiho largescalenetworkanalysisrevealsthesequencespacearchitectureofantibodyrepertoires AT rokroskar largescalenetworkanalysisrevealsthesequencespacearchitectureofantibodyrepertoires AT victorgreiff largescalenetworkanalysisrevealsthesequencespacearchitectureofantibodyrepertoires AT saitreddy largescalenetworkanalysisrevealsthesequencespacearchitectureofantibodyrepertoires
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Large-scale network analysis reveals the sequence space architecture of antibody repertoires

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