Recoding of the Vesicular Stomatitis Virus L Gene by Computer-Aided Design Provides a Live, Attenuated Vaccine Candidate

ABSTRACT Codon pair bias (CPB), which has been observed in all organisms, is a neglected genomic phenomenon that affects gene expression. CPB results from synonymous codons that are paired more or less frequently in ORFeomes regardless of codon bias. The effect of an individual codon pair change is...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Bingyin Wang, Chen Yang, Gergely Tekes, Steffen Mueller, Aniko Paul, Sean P. J. Whelan, Eckard Wimmer
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2015
Materias:
Acceso en línea:https://doaj.org/article/f6b22fa52b7d4a6eb4bb2ee70f7abc01
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!