Recoding of the Vesicular Stomatitis Virus L Gene by Computer-Aided Design Provides a Live, Attenuated Vaccine Candidate

ABSTRACT Codon pair bias (CPB), which has been observed in all organisms, is a neglected genomic phenomenon that affects gene expression. CPB results from synonymous codons that are paired more or less frequently in ORFeomes regardless of codon bias. The effect of an individual codon pair change is...

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Auteurs principaux: Bingyin Wang, Chen Yang, Gergely Tekes, Steffen Mueller, Aniko Paul, Sean P. J. Whelan, Eckard Wimmer
Format: article
Langue:EN
Publié: American Society for Microbiology 2015
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Accès en ligne:https://doaj.org/article/f6b22fa52b7d4a6eb4bb2ee70f7abc01
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