A Single Native Ganglioside GM<sub>1</sub>-Binding Site Is Sufficient for Cholera Toxin To Bind to Cells and Complete the Intoxication Pathway

A Single Native Ganglioside GM<sub>1</sub>-Binding Site Is Sufficient for Cholera Toxin To Bind to Cells and Complete the Intoxication Pathway

ABSTRACT Cholera toxin (CT) from Vibrio cholerae is responsible for the majority of the symptoms of the diarrheal disease cholera. CT is a heterohexameric protein complex with a 240-residue A subunit and a pentameric B subunit of identical 103-residue B polypeptides. The A subunit is proteolytically...

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Autores principales: Michael G. Jobling, ZhiJie Yang, Wendy R. Kam, Wayne I. Lencer, Randall K. Holmes
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2012
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/f6b94cc25bd8432ba19d50729f26c1eb
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