Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma
Fbxo4 tumour suppressor is part of a SCF E3 ligase which has two known substrates. Here, the authors identify Fxr1 as a substrate of SCFFbxo4 and identify an inherent regulatory feedback loop in head and neck squamous cell carcinoma that results in the bypass of senescence and neoplastic progression...
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| Auteurs principaux: | , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2017
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/f6bd5ecc2e824f789e93a0871d433086 |
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