Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma

Fbxo4 tumour suppressor is part of a SCF E3 ligase which has two known substrates. Here, the authors identify Fxr1 as a substrate of SCFFbxo4 and identify an inherent regulatory feedback loop in head and neck squamous cell carcinoma that results in the bypass of senescence and neoplastic progression...

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Autores principales:	Shuo Qie, Mrinmoyee Majumder, Katarzyna Mackiewicz, Breege V. Howley, Yuri K. Peterson, Philip H. Howe, Viswanathan Palanisamy, J. Alan Diehl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6bd5ecc2e824f789e93a0871d433086
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spelling	oai:doaj.org-article:f6bd5ecc2e824f789e93a0871d4330862021-12-02T14:42:18ZFbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma10.1038/s41467-017-01199-82041-1723https://doaj.org/article/f6bd5ecc2e824f789e93a0871d4330862017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01199-8https://doaj.org/toc/2041-1723Fbxo4 tumour suppressor is part of a SCF E3 ligase which has two known substrates. Here, the authors identify Fxr1 as a substrate of SCFFbxo4 and identify an inherent regulatory feedback loop in head and neck squamous cell carcinoma that results in the bypass of senescence and neoplastic progression.Shuo QieMrinmoyee MajumderKatarzyna MackiewiczBreege V. HowleyYuri K. PetersonPhilip H. HoweViswanathan PalanisamyJ. Alan DiehlNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuo Qie Mrinmoyee Majumder Katarzyna Mackiewicz Breege V. Howley Yuri K. Peterson Philip H. Howe Viswanathan Palanisamy J. Alan Diehl Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma
description	Fbxo4 tumour suppressor is part of a SCF E3 ligase which has two known substrates. Here, the authors identify Fxr1 as a substrate of SCFFbxo4 and identify an inherent regulatory feedback loop in head and neck squamous cell carcinoma that results in the bypass of senescence and neoplastic progression.
format	article
author	Shuo Qie Mrinmoyee Majumder Katarzyna Mackiewicz Breege V. Howley Yuri K. Peterson Philip H. Howe Viswanathan Palanisamy J. Alan Diehl
author_facet	Shuo Qie Mrinmoyee Majumder Katarzyna Mackiewicz Breege V. Howley Yuri K. Peterson Philip H. Howe Viswanathan Palanisamy J. Alan Diehl
author_sort	Shuo Qie
title	Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma
title_short	Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma
title_full	Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma
title_fullStr	Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma
title_full_unstemmed	Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma
title_sort	fbxo4-mediated degradation of fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f6bd5ecc2e824f789e93a0871d433086
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Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma

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