Targeting eIF4F translation complex sensitizes B-ALL cells to tyrosine kinase inhibition

Abstract The mechanistic target of rapamycin (mTOR) is a kinase whose activation is associated with poor prognosis in pre-B cell acute lymphoblastic leukemia (B-ALL). These and other findings have prompted diverse strategies for targeting mTOR signaling in B-ALL and other B-cell malignancies. In cel...

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Auteurs principaux: Thanh-Trang Vo, Lee-or Herzog, Roberta Buono, Jong-Hoon Scott Lee, Sharmila Mallya, Madeleine R. Duong, Joshua Thao, Moran Gotesman, David A. Fruman
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Q
Accès en ligne:https://doaj.org/article/f6da06c10adf41ed853a873822db0706
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