Molecular basis of CTCF binding polarity in genome folding

Molecular basis of CTCF binding polarity in genome folding

The boundaries of topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin. Here the authors find that CTCF positions cohesin through its N-terminus but does not control its overall binding dynamics on chromatin, and show how...

Full description

Saved in:
Bibliographic Details
Main Authors: Elphège P. Nora, Laura Caccianini, Geoffrey Fudenberg, Kevin So, Vasumathi Kameswaran, Abigail Nagle, Alec Uebersohn, Bassam Hajj, Agnès Le Saux, Antoine Coulon, Leonid A. Mirny, Katherine S. Pollard, Maxime Dahan, Benoit G. Bruneau
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/f6dc9bfc9ad642cb9b1ef1ce345d967f
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/f6dc9bfc9ad642cb9b1ef1ce345d967f

Similar Items