Molecular basis of CTCF binding polarity in genome folding

The boundaries of topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin. Here the authors find that CTCF positions cohesin through its N-terminus but does not control its overall binding dynamics on chromatin, and show how...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elphège P. Nora, Laura Caccianini, Geoffrey Fudenberg, Kevin So, Vasumathi Kameswaran, Abigail Nagle, Alec Uebersohn, Bassam Hajj, Agnès Le Saux, Antoine Coulon, Leonid A. Mirny, Katherine S. Pollard, Maxime Dahan, Benoit G. Bruneau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6dc9bfc9ad642cb9b1ef1ce345d967f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f6dc9bfc9ad642cb9b1ef1ce345d967f
record_format	dspace
spelling	oai:doaj.org-article:f6dc9bfc9ad642cb9b1ef1ce345d967f2021-12-02T15:39:20ZMolecular basis of CTCF binding polarity in genome folding10.1038/s41467-020-19283-x2041-1723https://doaj.org/article/f6dc9bfc9ad642cb9b1ef1ce345d967f2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19283-xhttps://doaj.org/toc/2041-1723The boundaries of topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin. Here the authors find that CTCF positions cohesin through its N-terminus but does not control its overall binding dynamics on chromatin, and show how the orientation of CTCF binding sites translates into genome folding patterns.Elphège P. NoraLaura CaccianiniGeoffrey FudenbergKevin SoVasumathi KameswaranAbigail NagleAlec UebersohnBassam HajjAgnès Le SauxAntoine CoulonLeonid A. MirnyKatherine S. PollardMaxime DahanBenoit G. BruneauNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elphège P. Nora Laura Caccianini Geoffrey Fudenberg Kevin So Vasumathi Kameswaran Abigail Nagle Alec Uebersohn Bassam Hajj Agnès Le Saux Antoine Coulon Leonid A. Mirny Katherine S. Pollard Maxime Dahan Benoit G. Bruneau Molecular basis of CTCF binding polarity in genome folding
description	The boundaries of topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin. Here the authors find that CTCF positions cohesin through its N-terminus but does not control its overall binding dynamics on chromatin, and show how the orientation of CTCF binding sites translates into genome folding patterns.
format	article
author	Elphège P. Nora Laura Caccianini Geoffrey Fudenberg Kevin So Vasumathi Kameswaran Abigail Nagle Alec Uebersohn Bassam Hajj Agnès Le Saux Antoine Coulon Leonid A. Mirny Katherine S. Pollard Maxime Dahan Benoit G. Bruneau
author_facet	Elphège P. Nora Laura Caccianini Geoffrey Fudenberg Kevin So Vasumathi Kameswaran Abigail Nagle Alec Uebersohn Bassam Hajj Agnès Le Saux Antoine Coulon Leonid A. Mirny Katherine S. Pollard Maxime Dahan Benoit G. Bruneau
author_sort	Elphège P. Nora
title	Molecular basis of CTCF binding polarity in genome folding
title_short	Molecular basis of CTCF binding polarity in genome folding
title_full	Molecular basis of CTCF binding polarity in genome folding
title_fullStr	Molecular basis of CTCF binding polarity in genome folding
title_full_unstemmed	Molecular basis of CTCF binding polarity in genome folding
title_sort	molecular basis of ctcf binding polarity in genome folding
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f6dc9bfc9ad642cb9b1ef1ce345d967f
work_keys_str_mv	AT elphegepnora molecularbasisofctcfbindingpolarityingenomefolding AT lauracaccianini molecularbasisofctcfbindingpolarityingenomefolding AT geoffreyfudenberg molecularbasisofctcfbindingpolarityingenomefolding AT kevinso molecularbasisofctcfbindingpolarityingenomefolding AT vasumathikameswaran molecularbasisofctcfbindingpolarityingenomefolding AT abigailnagle molecularbasisofctcfbindingpolarityingenomefolding AT alecuebersohn molecularbasisofctcfbindingpolarityingenomefolding AT bassamhajj molecularbasisofctcfbindingpolarityingenomefolding AT agneslesaux molecularbasisofctcfbindingpolarityingenomefolding AT antoinecoulon molecularbasisofctcfbindingpolarityingenomefolding AT leonidamirny molecularbasisofctcfbindingpolarityingenomefolding AT katherinespollard molecularbasisofctcfbindingpolarityingenomefolding AT maximedahan molecularbasisofctcfbindingpolarityingenomefolding AT benoitgbruneau molecularbasisofctcfbindingpolarityingenomefolding
_version_	1718385967709028352

Molecular basis of CTCF binding polarity in genome folding

Ejemplares similares