Molecular basis of CTCF binding polarity in genome folding
The boundaries of topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin. Here the authors find that CTCF positions cohesin through its N-terminus but does not control its overall binding dynamics on chromatin, and show how...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2020
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/f6dc9bfc9ad642cb9b1ef1ce345d967f |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|