A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins

A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins

Protein phosphorylation helps to control many important cellular activities. Here the authors describe a genetic selection strategy to isolate designed ankyrin repeat proteins that bind specifically to phosphomodified targets.

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Bibliographic Details
Main Authors: Bunyarit Meksiriporn, Morgan B. Ludwicki, Erin A. Stephens, Allen Jiang, Hyeon-Cheol Lee, Dujduan Waraho-Zhmayev, Lutz Kummer, Fabian Brandl, Andreas Plückthun, Matthew P. DeLisa
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/f70795db157645a6a02bf6f3d05cdf0b
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Summary:Protein phosphorylation helps to control many important cellular activities. Here the authors describe a genetic selection strategy to isolate designed ankyrin repeat proteins that bind specifically to phosphomodified targets.

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