A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins

Protein phosphorylation helps to control many important cellular activities. Here the authors describe a genetic selection strategy to isolate designed ankyrin repeat proteins that bind specifically to phosphomodified targets.

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Autores principales:	Bunyarit Meksiriporn, Morgan B. Ludwicki, Erin A. Stephens, Allen Jiang, Hyeon-Cheol Lee, Dujduan Waraho-Zhmayev, Lutz Kummer, Fabian Brandl, Andreas Plückthun, Matthew P. DeLisa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f70795db157645a6a02bf6f3d05cdf0b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:f70795db157645a6a02bf6f3d05cdf0b2021-12-02T14:39:40ZA survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins10.1038/s41467-019-09854-y2041-1723https://doaj.org/article/f70795db157645a6a02bf6f3d05cdf0b2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09854-yhttps://doaj.org/toc/2041-1723Protein phosphorylation helps to control many important cellular activities. Here the authors describe a genetic selection strategy to isolate designed ankyrin repeat proteins that bind specifically to phosphomodified targets.Bunyarit MeksiripornMorgan B. LudwickiErin A. StephensAllen JiangHyeon-Cheol LeeDujduan Waraho-ZhmayevLutz KummerFabian BrandlAndreas PlückthunMatthew P. DeLisaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bunyarit Meksiriporn Morgan B. Ludwicki Erin A. Stephens Allen Jiang Hyeon-Cheol Lee Dujduan Waraho-Zhmayev Lutz Kummer Fabian Brandl Andreas Plückthun Matthew P. DeLisa A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins
description	Protein phosphorylation helps to control many important cellular activities. Here the authors describe a genetic selection strategy to isolate designed ankyrin repeat proteins that bind specifically to phosphomodified targets.
format	article
author	Bunyarit Meksiriporn Morgan B. Ludwicki Erin A. Stephens Allen Jiang Hyeon-Cheol Lee Dujduan Waraho-Zhmayev Lutz Kummer Fabian Brandl Andreas Plückthun Matthew P. DeLisa
author_facet	Bunyarit Meksiriporn Morgan B. Ludwicki Erin A. Stephens Allen Jiang Hyeon-Cheol Lee Dujduan Waraho-Zhmayev Lutz Kummer Fabian Brandl Andreas Plückthun Matthew P. DeLisa
author_sort	Bunyarit Meksiriporn
title	A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins
title_short	A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins
title_full	A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins
title_fullStr	A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins
title_full_unstemmed	A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins
title_sort	survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f70795db157645a6a02bf6f3d05cdf0b
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A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins

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