A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins
Protein phosphorylation helps to control many important cellular activities. Here the authors describe a genetic selection strategy to isolate designed ankyrin repeat proteins that bind specifically to phosphomodified targets.
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Main Authors: | Bunyarit Meksiriporn, Morgan B. Ludwicki, Erin A. Stephens, Allen Jiang, Hyeon-Cheol Lee, Dujduan Waraho-Zhmayev, Lutz Kummer, Fabian Brandl, Andreas Plückthun, Matthew P. DeLisa |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2019
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Subjects: | |
Online Access: | https://doaj.org/article/f70795db157645a6a02bf6f3d05cdf0b |
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