Engineering orthogonal dual transcription factors for multi-input synthetic promoters

Genetic circuits usually employ the same set of transcription factors which can act via repression or activation of the target promoter. Here the authors present dual activator-repressor switches, designed via directed evolution, for orthogonal logic gates and multi-input circuit architectures.

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Detalles Bibliográficos
Autores principales: Andreas K. Brödel, Alfonso Jaramillo, Mark Isalan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/f72dc6142a374e1c9bf71d80e2e3a5fe
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