Comparative efficacy of amphotericin B-loaded chitosan nanoparticles and free amphotericin B drug against Leishmania tropica

Comparative efficacy of amphotericin B-loaded chitosan nanoparticles and free amphotericin B drug against Leishmania tropica

Abstract Background The preparation of an effective drug delivery formulation is an urgent need to treat cutaneous leishmaniasis (CL). Pentavalent antimonials and Amphotericin B (AmB) are considered to treat leishmaniasis; however, their clinical usage is hampered by poor solubility, high cost, toxi...

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Main Authors: Aamir Sohail, Rahat Ullah Khan, Momin Khan, Mehvish Khokhar, Safat Ullah, Arshad Ali, Hazrat Bilal, Saadullah Khattak, Mirwaise Khan, Baseer Ahmad
Format: article
Language:EN
Published: SpringerOpen 2021
Subjects:
Amphotericin B
Antileishmanial activity
Cutaneous leishmaniasis
Chitosan nanoparticles
Drug delivery
MTT assay
Science
Q
Online Access:https://doaj.org/article/f76deb20fe7c444b9b927c5878e5baeb
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