Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

Pancreatic tumors are frequently divided into basal and classical subtypes. Here, the authors use single cell sequencing to investigate organoids derived from pancreatic cancer tissue and find a hierarchy of distinct cell states, and classical and basal cells existing within the same tumor.

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Autores principales:	Teresa G. Krieger, Solange Le Blanc, Julia Jabs, Foo Wei Ten, Naveed Ishaque, Katharina Jechow, Olivia Debnath, Carl-Stephan Leonhardt, Anamika Giri, Roland Eils, Oliver Strobel, Christian Conrad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f77b80eb08eb4c0a93db5169bb083e64
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spelling	oai:doaj.org-article:f77b80eb08eb4c0a93db5169bb083e642021-12-02T17:13:18ZSingle-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy10.1038/s41467-021-26059-42041-1723https://doaj.org/article/f77b80eb08eb4c0a93db5169bb083e642021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26059-4https://doaj.org/toc/2041-1723Pancreatic tumors are frequently divided into basal and classical subtypes. Here, the authors use single cell sequencing to investigate organoids derived from pancreatic cancer tissue and find a hierarchy of distinct cell states, and classical and basal cells existing within the same tumor.Teresa G. KriegerSolange Le BlancJulia JabsFoo Wei TenNaveed IshaqueKatharina JechowOlivia DebnathCarl-Stephan LeonhardtAnamika GiriRoland EilsOliver StrobelChristian ConradNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Teresa G. Krieger Solange Le Blanc Julia Jabs Foo Wei Ten Naveed Ishaque Katharina Jechow Olivia Debnath Carl-Stephan Leonhardt Anamika Giri Roland Eils Oliver Strobel Christian Conrad Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
description	Pancreatic tumors are frequently divided into basal and classical subtypes. Here, the authors use single cell sequencing to investigate organoids derived from pancreatic cancer tissue and find a hierarchy of distinct cell states, and classical and basal cells existing within the same tumor.
format	article
author	Teresa G. Krieger Solange Le Blanc Julia Jabs Foo Wei Ten Naveed Ishaque Katharina Jechow Olivia Debnath Carl-Stephan Leonhardt Anamika Giri Roland Eils Oliver Strobel Christian Conrad
author_facet	Teresa G. Krieger Solange Le Blanc Julia Jabs Foo Wei Ten Naveed Ishaque Katharina Jechow Olivia Debnath Carl-Stephan Leonhardt Anamika Giri Roland Eils Oliver Strobel Christian Conrad
author_sort	Teresa G. Krieger
title	Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
title_short	Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
title_full	Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
title_fullStr	Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
title_full_unstemmed	Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
title_sort	single-cell analysis of patient-derived pdac organoids reveals cell state heterogeneity and a conserved developmental hierarchy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f77b80eb08eb4c0a93db5169bb083e64
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Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

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