The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

Translation of aberrant mRNAs causes ribosome stalling and translation arrest, followed by recycling of the stalled ribosome complex. Here the authors show that the Zinc Finger Protein 598 (ZNF598/Hel2) is implicated in sensing faulty translation of prematurely polyadenylated mRNAs through the recog...

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Autores principales:	Aitor Garzia, Seyed Mehdi Jafarnejad, Cindy Meyer, Clément Chapat, Tasos Gogakos, Pavel Morozov, Mehdi Amiri, Maayan Shapiro, Henrik Molina, Thomas Tuschl, Nahum Sonenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f79858e0db6542bdb89c353b12ea9953
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spelling	oai:doaj.org-article:f79858e0db6542bdb89c353b12ea99532021-12-02T14:42:10ZThe E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs10.1038/ncomms160562041-1723https://doaj.org/article/f79858e0db6542bdb89c353b12ea99532017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16056https://doaj.org/toc/2041-1723Translation of aberrant mRNAs causes ribosome stalling and translation arrest, followed by recycling of the stalled ribosome complex. Here the authors show that the Zinc Finger Protein 598 (ZNF598/Hel2) is implicated in sensing faulty translation of prematurely polyadenylated mRNAs through the recognition of AAA codons.Aitor GarziaSeyed Mehdi JafarnejadCindy MeyerClément ChapatTasos GogakosPavel MorozovMehdi AmiriMaayan ShapiroHenrik MolinaThomas TuschlNahum SonenbergNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aitor Garzia Seyed Mehdi Jafarnejad Cindy Meyer Clément Chapat Tasos Gogakos Pavel Morozov Mehdi Amiri Maayan Shapiro Henrik Molina Thomas Tuschl Nahum Sonenberg The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs
description	Translation of aberrant mRNAs causes ribosome stalling and translation arrest, followed by recycling of the stalled ribosome complex. Here the authors show that the Zinc Finger Protein 598 (ZNF598/Hel2) is implicated in sensing faulty translation of prematurely polyadenylated mRNAs through the recognition of AAA codons.
format	article
author	Aitor Garzia Seyed Mehdi Jafarnejad Cindy Meyer Clément Chapat Tasos Gogakos Pavel Morozov Mehdi Amiri Maayan Shapiro Henrik Molina Thomas Tuschl Nahum Sonenberg
author_facet	Aitor Garzia Seyed Mehdi Jafarnejad Cindy Meyer Clément Chapat Tasos Gogakos Pavel Morozov Mehdi Amiri Maayan Shapiro Henrik Molina Thomas Tuschl Nahum Sonenberg
author_sort	Aitor Garzia
title	The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs
title_short	The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs
title_full	The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs
title_fullStr	The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs
title_full_unstemmed	The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs
title_sort	e3 ubiquitin ligase and rna-binding protein znf598 orchestrates ribosome quality control of premature polyadenylated mrnas
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f79858e0db6542bdb89c353b12ea9953
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The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

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