GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis

Spondyloarthritis pathology is manifested by increased myeloid infiltration of the joints. Here the authors show that in a mouse model of spondyloarthritis, a single dose of a microbial ligand curdlan induces persistent extramedullary myelopoiesis in the spleen and joints, which is driven by GM-CSF...

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Autores principales: Daniel Regan-Komito, James W. Swann, Philippos Demetriou, E. Suzanne Cohen, Nicole J. Horwood, Stephen N. Sansom, Thibault Griseri
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/f7b103b252e947a39c14dfd402497151
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