GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis

Spondyloarthritis pathology is manifested by increased myeloid infiltration of the joints. Here the authors show that in a mouse model of spondyloarthritis, a single dose of a microbial ligand curdlan induces persistent extramedullary myelopoiesis in the spleen and joints, which is driven by GM-CSF...

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Autores principales:	Daniel Regan-Komito, James W. Swann, Philippos Demetriou, E. Suzanne Cohen, Nicole J. Horwood, Stephen N. Sansom, Thibault Griseri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7b103b252e947a39c14dfd402497151
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spelling	oai:doaj.org-article:f7b103b252e947a39c14dfd4024971512021-12-02T16:56:51ZGM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis10.1038/s41467-019-13853-42041-1723https://doaj.org/article/f7b103b252e947a39c14dfd4024971512020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13853-4https://doaj.org/toc/2041-1723Spondyloarthritis pathology is manifested by increased myeloid infiltration of the joints. Here the authors show that in a mouse model of spondyloarthritis, a single dose of a microbial ligand curdlan induces persistent extramedullary myelopoiesis in the spleen and joints, which is driven by GM-CSF and can be amplified by exogenous IL-33.Daniel Regan-KomitoJames W. SwannPhilippos DemetriouE. Suzanne CohenNicole J. HorwoodStephen N. SansomThibault GriseriNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Regan-Komito James W. Swann Philippos Demetriou E. Suzanne Cohen Nicole J. Horwood Stephen N. Sansom Thibault Griseri GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis
description	Spondyloarthritis pathology is manifested by increased myeloid infiltration of the joints. Here the authors show that in a mouse model of spondyloarthritis, a single dose of a microbial ligand curdlan induces persistent extramedullary myelopoiesis in the spleen and joints, which is driven by GM-CSF and can be amplified by exogenous IL-33.
format	article
author	Daniel Regan-Komito James W. Swann Philippos Demetriou E. Suzanne Cohen Nicole J. Horwood Stephen N. Sansom Thibault Griseri
author_facet	Daniel Regan-Komito James W. Swann Philippos Demetriou E. Suzanne Cohen Nicole J. Horwood Stephen N. Sansom Thibault Griseri
author_sort	Daniel Regan-Komito
title	GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis
title_short	GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis
title_full	GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis
title_fullStr	GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis
title_full_unstemmed	GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis
title_sort	gm-csf drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f7b103b252e947a39c14dfd402497151
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GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis

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